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OpenFold3

A community, bitwise-faithful open reproduction of AlphaFold 3

WebsiteSource codeDocumentation

What's new

OpenFold3-preview is public for community feedback — notably the only open model to match AlphaFold 3 on monomeric RNA structures.

OpenFold3 is the next generation of the OpenFold project, aiming to be a bitwise-faithful, fully trainable reproduction of AlphaFold 3. It is developed by the AlQuraishi Lab at Columbia University together with the OpenFold Consortium.

Highlights

  • Apache-2.0 and free for academic and commercial use, with training data released.
  • Competitive with the state of the art in open structure prediction.
  • The only open model reported to match AlphaFold 3 on monomeric RNA structures.

The project is a research preview; the final model and training pipeline are still in active development.

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